APTX 4869
APTX 4869 is a toxin that features in Case Closed.
Contents |
History
Apoptoxin 4869 (Japanese: アポトキシン よんはちろくきゅう, Hepburn Apotokishin Yon-Hachi-Roku-Kyū?) (APTX4869) was a prototype experimental poison that was developed by Dr. Shiho Miyano. Atsushi Miyano and Elena Miyano joined the Black Organization as researchers around some months before Shiho Miyano was born and started developing APTX 4869. Vermouth may have hinted that there was an earlier project that the Miyanos assumed control over when they joined, perhaps the one Shiho implied was at least 50 years old. Regardless, the pair worked on APTX 4869 until they met their untimely deaths in a laboratory fire which destroyed much of their research, leaving their daughter Shiho Miyano behind and the project in an unfinished state. The Miyano parents' version of the APTX 4869 was used to kill at least one person, Kohji Haneda who was murdered 17 years ago and included on Shiho's list of APTX victims.
Shiho was then groomed to take over their APTX 4869 research project. She was educated overseas in America before returning to Japan at or before she was 13. Shiho advanced the drug to the point where she observed at least one of her lab mice reverting in age. She was also ordered to test the most recent, yet still incomplete, version of APTX 4869 on Ki'ichiro Numabuchi, a failed assassin. Shiho received the data about him, but he managed to escape the Black Organization before she could test it on him. The drug was still considered incomplete by the time it was used on Shinichi Kudo, but Pisco implied that Shiho had advanced it significantly since her parents' tenure. Shiho boycotted her work, when she could not get any answer to why her sister had died. To die by her own hand, she used the poison and ended up getting shrunk, which made her able to escape. It is unknown if the Black Organization has found replacement researchers to continue work on the APTX 4869 project after Shiho's defection. Sometime during APTX's development, the Black Organization decided to use the incomplete form as a poison for stealthy murder, since it could kill without leaving a trace in the victim.
Overview
It was nicknamed the Incomplete Detective by members of the Black Organization.
Use of the toxin involved the activation of apoptosis: the mechanism by which cells kill themselves. APTX contains ingredients which have other functions as well. It contained a component which activates telomerase: an enzyme which lengthens the caps at the end of DNA whose length limits the number of times a cell can divide.
Users
- Shiho Miyano :
Notes
- APTX 4869 was created by Gosho Aoyama where it featured in the setting of the Case Closed universe.
In other media
Television
Appearances
- Case Closed:
External Links
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