Dr. Kettering was a colleague of Ludwig Frankenstein in the town of Visaria. Regarded by everyone as a kind and gentle person, Kettering was tragically killed when the crazed Frankenstein Monster broke into Ludwig's home and attacked him while trying to abduct Elsa. Although Ludwig tried to save the mortally wounded Kettering using his medical skills, he failed and Kettering died. To make amends (and to end the threat of the Monster forever), Ludwig planned to remove the Monster's criminal brain and replace it with Kettering's, thus giving his colleague a new lease on life. Unfortunately, the mad cripple named Ygor ruined the doctor's plans.