The U.S.S. Fleming was a United Federation of Planets starship, Wambundu-class, NCC-20316. A medical transport, the Fleming was transporting a rare and valuable biomimetic gel, before it disappeared in the Hekaras Corridor in 2370. The ship was feared to have fallen prey to hijackers, but it had actually been disabled by a Hekaran verteron mine. The U.S.S. Enterprise-D discovered it, but a subspace rift opened soon after the Fleming was found and entrapped the ship. The Enterprise was able to rescue the crew, but not the ship, which was destroyed.