Dr. Wheelo was a brilliant human scientist who performed experiments in biotechnology. Wheelo's ultimate goal was to modify the human race using his science. Before he could realize his goal, he died of natural causes, but his faithful android assistant Dr. Kochin transplanted his mentor's brain into a cumbersome robot body, allowing Wheelo to survive. However, an avalanche of ice and snow sealed him in his laboratory in the Tsurumaitsuburi Mountains.
Dr. Kochin came through for his creator a second time fifty years later when he gathered the Dragon Balls and asked the Eternal Dragon Shenron to thaw the ice-enshrouded fortress. Freed from his frozen sleep, Wheelo became obsessed with finding the world's strongest man so that his own brain might be transplanted into it. He sent Kochin and four Bio-Men to find this man, and at first they thought it was Master Roshi. But when Kishime, Misokatsun and Ebifurya easily beat Roshi, Wheelo realized they had the wrong person.
Roshi, however, did serve a purpose: his capture lured Goku to the Tsurumaitsuburi Mountains. Wheelo, who had learned from Bulma that Goku is the man he sought, sent his biotechnical warriors to defeat Goku so that the brain transplant procedure could begin.
Goku proved to be far too much for the trio to handle, and defeated them with the help of Gohan and Krillin. When Wheelo's further attempts to subdue Goku met with failure, the enraged scientist decided to kill him and all friends. When that also failed, Wheelo, who by this point was completely out of his mind (no pun intended), decided to just concentrate the energy contained within his laboratory's power core to destroy the entire world. Luckily for everyone (and with everyone's help, conversely), Goku was able to form a Spirit Bomb (Genki-Dama) and used it to destroy Wheelo for good.